Shi LH, Jin DZ, Zhou WC, Wang J, Chen XH
[Design and synthesis of 3'-methyl-furanonucleosides and their anti-tumor activities] [English Abstract, Journal Article]
Yao Xue Xue Bao 2009 Jul; 44(7):747-53.
Taking 3'-Me-Ado (3'-methyladenosine) and Cladribine as the leading compounds, seventeen 3'-C-methyl-furanonucleosides were designed and synthesized. All the structures were confirmed by 1H NMR and MS. The target compounds were tested in vitro against human pulmonary carcinoma A549, human colon carcinoma LOVO and human leukemia CEM by MTT assay. The results showed that these compounds possessed moderate cytotoxities.
More from this journal |
